Sensitive Quantitation of Residual Phenylhydrazine in Antipyrine by LC-ICP-MS with Iodo Derivatization
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- HARIGAYA Koki
- Analytical Research Laboratories, CMC Division, Mitsubishi Tanabe Pharma Corp.
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- YAMADA Hiroyuki
- Analytical Research Laboratories, CMC Division, Mitsubishi Tanabe Pharma Corp.
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- HORIMOTO Shingo
- Analytical Research Laboratories, CMC Division, Mitsubishi Tanabe Pharma Corp.
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- NISHI Hiroyuki
- Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yasuda Women’s University
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- HAGINAKA Jun
- School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University
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Abstract
Phenylhydrazine is a genotoxic impurity commonly used as a raw material in active pharmaceutical ingredients. In this study, a novel method, using inductively coupled plasma–mass spectrometry combined with two-dimensional liquid chromatography (LC-ICP-MS), was employed for the quantitation of residual phenylhydrazine in antipyrine. The compound 2,3,5-triiodobenzoyl chloride, which contains three iodine atoms, was investigated as a derivatization reagent. The DL 0.06 ppm was obtained, and the method was applied to the quantitation of residual phenylhydrazine in antipyrine. No residual phenylhydrazine was detected in five lots of antipyrine obtained from the commercial source.
Journal
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- Analytical Sciences
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Analytical Sciences 30 (8), 845-850, 2014
The Japan Society for Analytical Chemistry
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Keywords
Details 詳細情報について
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- CRID
- 1390282679236575872
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- NII Article ID
- 130004677861
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- NII Book ID
- AA10500785
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- COI
- 1:STN:280:DC%2BC2M%2Fgs1Oruw%3D%3D
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- ISSN
- 13482246
- 09106340
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- NDL BIB ID
- 025633325
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- PubMed
- 25109648
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- Web Site
- http://id.ndl.go.jp/bib/025633325
- https://ndlsearch.ndl.go.jp/books/R000000004-I025633325
- https://link.springer.com/content/pdf/10.2116/analsci.30.845.pdf
- https://link.springer.com/article/10.2116/analsci.30.845/fulltext.html
- https://www.jstage.jst.go.jp/article/analsci/30/8/30_845/_pdf
- https://search.jamas.or.jp/link/ui/2015062393
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed