BODIPY-labeled Fluorescent Aptamer Sensors for Turn-on Sensing of Interferon-gamma and Adenine Compounds on Cells
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- TSUCHIYA Akira
- Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
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- HASHIM Siti N.
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University
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- ISE Shoko
- Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
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- FURUHATA Takafumi
- Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
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- KAWAI Kiyohiko
- The Institute of Scientific and Industrial Research, Osaka University
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- WAKABAYASHI Rie
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University
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- GOTO Masahiro
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University Center for Future Chemistry, Kyushu University
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- KAMIYA Noriho
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University Center for Future Chemistry, Kyushu University
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- SANDO Shinsuke
- Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
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Abstract
An on-cell aptamer sensor has the potential to reveal cell–cell communications by signalling molecules. We attempted to design new fluorescent aptamer sensors for the sensing of IFN-γ and adenine compounds on cells. BODIPY-labeled external quencher-free aptamer sensors have allowed a turn-on detection of the target molecule with improved off/on efficiency.
Journal
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- Analytical Sciences
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Analytical Sciences 32 (5), 543-547, 2016
The Japan Society for Analytical Chemistry
