Self-assembled Nanowire Arrays as Three-dimensional Nanopores for Filtration of DNA Molecules

DOI PDF Web Site Web Site Web Site ほか1件をすべて表示 一部だけ表示 被引用文献4件 参考文献22件 オープンアクセス
  • RAHONG Sakon
    Institute of Innovation for Future Society, Nagoya University FIRST Research Center for Innovative Nanobiodevices, Nagoya University
  • YASUI Takao
    FIRST Research Center for Innovative Nanobiodevices, Nagoya University Department of Applied Chemistry, Graduate School of Engineering, Nagoya University
  • YANAGIDA Takeshi
    The Institute of Scientific and Industrial Research, Osaka University
  • NAGASHIMA Kazuki
    The Institute of Scientific and Industrial Research, Osaka University
  • KANAI Masaki
    The Institute of Scientific and Industrial Research, Osaka University
  • MENG Gang
    The Institute of Scientific and Industrial Research, Osaka University
  • HE Yong
    The Institute of Scientific and Industrial Research, Osaka University
  • ZHUGE Fuwei
    The Institute of Scientific and Industrial Research, Osaka University
  • KAJI Noritada
    FIRST Research Center for Innovative Nanobiodevices, Nagoya University Department of Applied Chemistry, Graduate School of Engineering, Nagoya University
  • KAWAI Tomoji
    The Institute of Scientific and Industrial Research, Osaka University
  • BABA Yoshinobu
    FIRST Research Center for Innovative Nanobiodevices, Nagoya University Department of Applied Chemistry, Graduate School of Engineering, Nagoya University Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

この論文をさがす

説明

Molecular filtration and purification play important roles for biomolecule analysis. However, it is still necessary to improve efficiency and reduce the filtration time. Here, we show self-assembled nanowire arrays as three-dimensional (3D) nanopores embedded in a microfluidic channel for ultrafast DNA filtration. The 3D nanopore structure was formed by a vapor-liquid-solid (VLS) nanowire growth technique, which allowed us to control pore size of the filtration material by varying the number of growth cycles. λ DNA molecules (48.5 kbp) were filtrated from a mixture of T4 DNA (166 kbp) at the entrance of the 3D nanopore structure within 1 s under an applied electric field. Moreover, we observed single DNA molecule migration of T4 and λ DNA molecules to clarify the filtration mechanism. The 3D nanopore structure has simplicity of fabrication, flexibility of pore size control and reusability for biomolecule filtration. Consequently it is an excellent material for biomolecular filtration.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 31 (3), 153-157, 2015

    社団法人 日本分析化学会

被引用文献 (4)*注記

もっと見る

参考文献 (22)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ