Development and Validation of a New HPLC Method for the Simultaneous Determination of Paracetamol, Ascorbic Acid, and Pseudoephedrine HCl in their Co-formulated Tablets : Application to in vitro Dissolution Testing
-
- IBRAHIM Fawzia
- Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura
-
- EL-ENANY Nahed
- Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura
-
- EL-SHAHENY Rania N.
- Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura
-
- MIKHAIL Ibraam E.
- Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura
書誌事項
- タイトル別名
-
- Development and Validation of a New HPLC Method for the Simultaneous Determination of Paracetamol, Ascorbic Acid, and Pseudoephedrine HCl in their Co-formulated Tablets. Application to <i>in vitro</i> Dissolution Testing
- 公開日
- 2015
- 資源種別
- journal article
- DOI
-
- 10.2116/analsci.31.943
- 公開者
- 社団法人 日本分析化学会
この論文をさがす
説明
The first HPLC method was developed for the simultaneous determination of paracetamol (PC), ascorbic acid (AA), and pseudoephedrine HCl (PE) in their co-formulated tablets. Separation was achieved on a C18 column in 5 min using a mobile phase composed of methanol-0.05 M phosphate buffer (35:65, v/v) at pH 2.5 with UV detection at 220 nm. Linear calibration curves were constructed over concentration ranges of 1.0 – 50.0, 3.0 – 60.0 and 3.0 – 80.0 μg mL−1 for PC, AA, and PE, respectively. The method was validated and applied for the simultaneous determination of these drugs in their tablets with average % recoveries of 101.17 ± 0.67, 98.34 ± 0.77, and 98.95 ± 1.11%, for PC, AA, and PE, respectively. The proposed method was also used to construct in vitro dissolution profiles of the co-formulated tablets containing the three drugs.
収録刊行物
-
- Analytical Sciences
-
Analytical Sciences 31 (9), 943-947, 2015
社団法人 日本分析化学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679236991872
-
- NII論文ID
- 130005097920
-
- NII書誌ID
- AA10500785
-
- ISSN
- 13482246
- 09106340
-
- NDL書誌ID
- 026735765
-
- PubMed
- 26353962
-
- Web Site
- http://id.ndl.go.jp/bib/026735765
- https://ndlsearch.ndl.go.jp/books/R000000004-I026735765
- https://link.springer.com/content/pdf/10.2116/analsci.31.943.pdf
- https://link.springer.com/article/10.2116/analsci.31.943/fulltext.html
- https://www.jstage.jst.go.jp/article/analsci/31/9/31_943/_pdf
- https://search.jamas.or.jp/link/ui/2016154600
-
- 本文言語コード
- en
-
- 資料種別
- journal article
-
- データソース種別
-
- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可
