Application of Terahertz Absorption Spectroscopy to Evaluation of Aging Variation of Medicine
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- KAWASE Masaya
- Nagahama Institute of Bio-science and Technology Radioisotope Research Center, Osaka University
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- SAITO Tadashi
- Radioisotope Research Center, Osaka University
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- OGAWA Masafumi
- Faculty of Pharmaceutical Sciences, Osaka Ohtani University
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- UEJIMA Hideki
- Faculty of Pharmaceutical Sciences, Osaka Ohtani University
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- HATSUDA Yasutoshi
- Faculty of Pharmaceutical Sciences, Osaka Ohtani University
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- KAWANISHI Sonoyo
- Faculty of Pharmaceutical Sciences, Osaka Ohtani University
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- HIROTANI Yoshihiko
- Faculty of Pharmaceutical Sciences, Osaka Ohtani University
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- MYOTOKU Michiaki
- Faculty of Pharmaceutical Sciences, Osaka Ohtani University
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- IKEDA Kenji
- Faculty of Pharmaceutical Sciences, Osaka Ohtani University
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- KONISHI Hiroki
- Faculty of Pharmaceutical Sciences, Osaka Ohtani University
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- IGA Ikumi
- Faculty of Pharmaceutical Sciences, Osaka Ohtani University
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- YAMAKAWA Junji
- Graduate School of Natural Science and Technology, Okayama University
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- NISHIZAWA Seizi
- Advanced Infrared Spectroscopy
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- YAMAMOTO Kohji
- Research Center for Development of Far-Infrared Region, University of Fukui
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- TANI Masahiko
- Research Center for Development of Far-Infrared Region, University of Fukui
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Abstract
The absorption spectra of three kinds of medicines both before and after the expiration date: Amlodin OD® (5 mg), Basen OD® (0.2 mg) and Gaster D® (10 mg) have been measured by terahertz time domain spectroscopy (THz-TDS). All the medicines show some differences in the THz absorption spectra between medicines before and after the expiration dates. X-Ray powder diffraction (XRD) studies of all medicines suggest that the polymorph of the main effective compound is not changed before and after the expiration date. Therefore, the differences in the THz spectra between medicines before and after the expiration dates arise from aging variation of diluting agents and/or from modifications of intermolecular interaction between the effective compounds and diluting agents.
Journal
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- Analytical Sciences
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Analytical Sciences 27 (2), 209-, 2011
The Japan Society for Analytical Chemistry
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Keywords
Details 詳細情報について
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- CRID
- 1390282679237110016
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- NII Article ID
- 10027905928
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- NII Book ID
- AA10500785
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- COI
- 1:STN:280:DC%2BC3M7pt12hsg%3D%3D
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- ISSN
- 13482246
- 09106340
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- NDL BIB ID
- 10970736
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- PubMed
- 21321447
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- Web Site
- http://id.ndl.go.jp/bib/10970736
- https://ndlsearch.ndl.go.jp/books/R000000004-I10970736
- https://link.springer.com/content/pdf/10.2116/analsci.27.209.pdf
- https://link.springer.com/article/10.2116/analsci.27.209/fulltext.html
- http://www.jstage.jst.go.jp/article/analsci/27/2/27_2_209/_pdf
- https://search.jamas.or.jp/link/ui/2011323319
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed
