Implantable Patch Sensor for L-Glutamate in Hippocampal Slices
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- SOMA Natsumi
- Department of Chemistry, College of Humanities and Sciences, Nihon University
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- WATANABE Narumi
- Department of Chemistry, College of Humanities and Sciences, Nihon University
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- SHOJI Atsushi
- Department of Chemistry, College of Humanities and Sciences, Nihon University
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- SUGAWARA Masao
- Department of Chemistry, College of Humanities and Sciences, Nihon University
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We describe an implantable patch sensor for monitoring L-glutamate in hippocampal slices in submerged and interface preparations. This patch sensor is prepared by excising the cell membrane in the CA3 region of a hippocampal slice in a submerged preparation, and then implanted in the target neuronal region (CA1) of mouse hippocampal slices. The lifetime of the sensor was 3 – 8 min for the interface slice and 40 – 50 min for the submerged slice. The calibration of an implanted sensor can be achieved by adding an L-glutamate solution to a bath (ACSF) solution. The monitoring of L-glutamate release in the CA1 region of mouse hippocampal slices under chemical stimulation with γ-aminobutyric acid (GABA) and potassium chloride (KCl) was demonstrated.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 29 (2), 181-185, 2013
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679237423488
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- NII論文ID
- 10031156853
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- NII書誌ID
- AA10500785
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- COI
- 1:STN:280:DC%2BC3sznsVeiuw%3D%3D
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 024257759
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- PubMed
- 23400282
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I024257759
- https://link.springer.com/content/pdf/10.2116/analsci.29.181.pdf
- https://link.springer.com/article/10.2116/analsci.29.181/fulltext.html
- https://www.jstage.jst.go.jp/article/analsci/29/2/29_181/_pdf
- https://search.jamas.or.jp/link/ui/2013249108
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
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