Separation of Parabens on a Zirconia-Based Stationary Phase in Superheated Water Chromatography

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  • YARITA Takashi
    National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST)
  • AOYAGI Yoshie
    National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST)
  • SASAI Haruka
    Faculty of Science, Toho University
  • NISHIGAKI Atsuko
    Faculty of Science, Toho University
  • SHIBUKAWA Masami
    Graduate School of Science and Engineering, Saitama University

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Abstract

A superheated water chromatography (SWC) method for the separation of alkyl esters of 4-hydroxybenzoic acid (parabens) using a zirconia-based stationary phase was developed and applied to real sample analysis. First, the SWC system was optimized in terms of the proper length of the preheating coil for establishing thermal equilibration of the mobile phase entering the column at the oven temperature. Next, the effect of the column temperature on the retention was investigated at 100 – 180°C. The elution time for all parabens decreased with increasing column temperature, and linear relationships between ln k and 1/T were obtained. At higher column temperatures, the elution time was further shortened because of the increased mobile-phase flow rate. Nevertheless, the loss of column efficiency at the higher flow rates was not significant. The application of the present method to the analysis of commercial lotions was then demonstrated. The quantification results obtained from SWC showed good agreement with those from a conventional HPLC method.

Journal

  • Analytical Sciences

    Analytical Sciences 29 (2), 213-219, 2013

    The Japan Society for Analytical Chemistry

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