Differential Pulse Anodic Voltammetric Determination of Tiapride Hydrochloride in Pharmaceutical Preparation and Human Urine Using Carbon Paste Electrodes

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The anodic voltammetric behavior of tiapride hydrochloride (TiapCl) was studied at carbon paste electrodes in 0.04 M Britton–Robinson buffer pH 7.0 using cyclic and differential pulse voltammetric techniques. The oxidation of TiapCl is an irreversible diffusion-controlled process. A differential pulse anodic voltammetric procedure has been developed for determination of the drug over the concentration range 0.36 – 19.35 μg/ml with detection and quantification limits of 0.12 and 0.40 μg/ml, respectively. The proposed method was successfully applied for the determination of the drug in commercial tablets and in spiked human urine samples.

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  • Analytical Sciences

    Analytical Sciences 27 (5), 535-, 2011

    社団法人 日本分析化学会

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