Detection and Quantification of 4-Methylimidazole in Cola by Matrix-assisted Laser Desorption Ionization Mass Spectrometry with Fe<sub>2</sub>O<sub>3</sub> Nanoparticles on Zeolite

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  • FUJII Yosuke
    Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University
  • DING Yuqi
    Department of Food Inspection, Zhejiang Institute for Food and Drug Control
  • UMEZAWA Taichi
    Department of Applied Chemistry, Graduate School of Science and Engineering, Toyo University
  • AKIMOTO Takafumi
    Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University
  • XU Jiawei
    Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University
  • UCHIDA Takashi
    Bio-Nano Electronics Research Centre, Toyo University
  • FUJINO Tatsuya
    Department of Applied Chemistry, Graduate School of Science and Engineering, Toyo University Bio-Nano Electronics Research Centre, Toyo University

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  • Detection and Quantification of 4-Methylimidazole in Cola by Matrix-assisted Laser Desorption Ionization Mass Spectrometry with Fe₂O₃ Nanoparticles on Zeolite
  • Detection and Quantification of 4-Methyliniidazole in Cola by Matrix-assisted Laser Desorption Ionization Mass Spectrometry with Fe2O3 Nanoparticles on Zeolite

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Description

Food additives generally used in carbonated drinks, such as 4-methylimidazole (4MI), caffeine (Caf?), citric acid (CA), and aspartame (Apm), were measured by matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) using nanometer-sized particles of iron oxide (Fe2O3 NPs). The quantification of 4MI in Coca Cola (C-cola) was carried out. In order to improve the reproducibility of the peak intensities, Fe2O3 NPs loaded on ZSM5 zeolite were used as the matrix for quantification. By using 2-ethylimidazole (2EI) as the internal standard, the amount of 4MI in C-cola was determined to range from 88 to 65 μg/355 mL. The results agree with the published value (approx. 72 μg/355 mL). It was found that MALDI using Fe2O3 was applicable to the quantification of 4MI in C-cola.

Journal

  • Analytical Sciences

    Analytical Sciences 34 (2), 221-225, 2018

    The Japan Society for Analytical Chemistry

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