Microfluidic Device for Coulometric Detection of Organophosphate Pesticides
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- WANG Jin
- Graduate School of Life and Environmental Sciences, University of Tsukuba
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- SATAKE Takaaki
- Graduate School of Life and Environmental Sciences, University of Tsukuba
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- SUZUKI Hiroaki
- Graduate School of Pure and Applied Sciences, University of Tsukuba
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説明
A microdevice for coulometric detection of organophosphate pesticides (OPs) was fabricated based on the measurement of the inhibition of an enzyme, acetylcholinesterase (AChE), by OPs. Thiocholine (TCh) produced in the enzymatic reaction of AChE with acetylthiocholine (ATCh) as a substrate was oxidized on a microelectrode array formed in a main flow channel. Volumes of plugs of necessary solutions were measured using a structure consisting of a row of rhombuses formed in an auxiliary flow channel. The plugs were merged and solution components were mixed at a T-junction formed with the main and auxiliary flow channels. A linear relationship was confirmed between the generated charge and the logarithm of the OP (malathion) concentration in a concentration range between 10−6 and 10−3 M with a correlation coefficient of 0.951. The lower limit of detection was 412 nM.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 31 (7), 591-595, 2015
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679238041472
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- NII論文ID
- 130005087174
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- NII書誌ID
- AA10500785
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 026581545
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- PubMed
- 26165279
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDLサーチ
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- PubMed
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- 使用不可