Detection of Pb²⁺ in Aqueous Solution by Using a DNA-modified Microcantilever

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  • PENG Rong-Peng
    Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences and Graduate University of Chinese Academy of Sciences College of Chemistry, Nanchang University Department of Chemistry, Drexel University
  • XING Ling-Bao
    Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences and Graduate University of Chinese Academy of Sciences
  • WANG Xiao-Jun
    Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences and Graduate University of Chinese Academy of Sciences
  • WU Cheng-juan
    Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences and Graduate University of Chinese Academy of Sciences
  • CHEN Bin
    Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences and Graduate University of Chinese Academy of Sciences
  • JI Hai-Feng
    Department of Chemistry, Drexel University
  • WU Li-Zhu
    Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences and Graduate University of Chinese Academy of Sciences
  • TUNG Chen-Ho
    Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences and Graduate University of Chinese Academy of Sciences

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タイトル別名
  • Detection of Pb<sup>2+</sup> in Aqueous Solution by Using a DNA-modified Microcantilever

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説明

We developed a novel Pb2+-sensor based on a microcantilever that was modified with a specific Pb2+-dependent DNAzyme molecule. This microcantilever sensor could detect Pb2+ sensitively and selectively in an aqueous solution. Upon complexation with Pb2+, the DNAzyme duplex unwinded and formed a G-quadruplex conformation, which led to an increase of repulsion between the DNAzyme molecules and a subsequent bending of the microcantilever. This microcantilever sensor could be regenerated, flowing through a strong Pb2+ chelator, 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid. The detection limit of the microcantilever sensor for Pb2+ ions is as low as 10−8 M. The microcantilever sensor also exhibited a high selectivity to Pb2+ over other metal ions such as Mg2+, Fe3+, Zn2+, Ca2+, and Cd2+.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 32 (10), 1065-1069, 2016

    社団法人 日本分析化学会

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