Acetone Concentration in Gas Emanating from Tails of Diabetic Rats
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- YAMAI Kazuaki
- Material Science and Engineering, Graduate School of Engineering, Nagoya Institute of Technology
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- FUNADA Toshiaki
- Material Science and Engineering, Graduate School of Engineering, Nagoya Institute of Technology
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- OHKUWA Tetsuo
- Material Science and Engineering, Graduate School of Engineering, Nagoya Institute of Technology
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- ITOH Hiroshi
- Material Science and Engineering, Graduate School of Engineering, Nagoya Institute of Technology
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- TSUDA Takao
- Pico-Device Co., Ltd., Offices, Incubation Center
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Description
This study investigated the effects of diabetic rats induced by streptozotocin (STZ) on acetone concentration emanating from the tail of a rat. Experiments were carried out with male Wistar rats (9 weeks of age, 220 – 250 g body weight). Glucose concentration in the blood was 10.8 ± 0.7 mmol/l for the control group and 39.6 ± 2.4 mmol/l for the diabetic group. β-Hydroxybutyrate concentration in blood was 218 ± 52 μmol/l for the control group and 1439 ± 101 μmol/l for the diabetic group. Both glucose and β-hydroxybutyrate concentrations in the blood of the diabetic group were significantly higher than those of the control group (p < 0.001). Skin gas acetone concentration emanated from rat tail was 124 ± 46 ppb for control and 1134 ± 417 ppb for diabetic. Skin gas acetone concentration emitted from the tail of a rat with diabetes was significantly higher than that from a rat in the control group (p < 0.001). The result indicates that skin acetone emanating from a rat tail is a useful parameter to use for insulin-dependent diabetes (type I).
Journal
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- Analytical Sciences
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Analytical Sciences 28 (5), 511-514, 2012
The Japan Society for Analytical Chemistry
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Details 詳細情報について
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- CRID
- 1390282679238746752
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- NII Article ID
- 10030757677
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- NII Book ID
- AA10500785
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- COI
- 1:STN:280:DC%2BC38jgslyktA%3D%3D
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- ISSN
- 13482246
- 09106340
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- NDL BIB ID
- 023614014
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- PubMed
- 22687932
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- Web Site
- http://id.nii.ac.jp/1476/00005641/
- http://id.ndl.go.jp/bib/023614014
- https://ndlsearch.ndl.go.jp/books/R000000004-I023614014
- https://link.springer.com/content/pdf/10.2116/analsci.28.511.pdf
- https://link.springer.com/article/10.2116/analsci.28.511/fulltext.html
- https://www.jstage.jst.go.jp/article/analsci/28/5/28_511/_pdf
- https://search.jamas.or.jp/link/ui/2013001940
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL Search
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- PubMed
- CiNii Articles
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- OpenAIRE
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- Abstract License Flag
- Disallowed