頭頸部癌放射線粘膜炎に対するオピオイド投与―副作用と依存性―

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タイトル別名
  • Side Effects and Opioid Addiction in Radiation-Induced Mucositis Pain Control in Head and Neck Cancer
  • 薬物 頭頸部癌放射線粘膜炎に対するオピオイド投与--副作用と依存性
  • ヤクブツ トウケイブガン ホウシャセン ネンマクエン ニ タイスル オピオイド トウヨ フクサヨウ ト イソンセイ
  • ―副作用と依存性―

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Radiation therapy in head and neck malignancy may trigger mucositis poorly controlled by nonsteroidal antiinflammatory drugs (NSAIDs). Having already reported early opioid efficacy in radiation-induced mucositis pain in head and neck cancer, we discuss whether this resulted in severe side effects and opioid addiction.<br> Of 11 persons (26.2%) with nausea, 3 could not tolerate opioid. Of 33 (78.6%) with constipation, all were controlled by purgatives. Seven had mild sleepiness.<br> None had severe opioid side effects in radiation-induced mucositis pain treatment, but I showed opioid dependence after 128-days opioid administration.<br> While opioid administration in radiation-induced mucositis pain may not cause addiction, lomg-term opioid use should be carefully monitored.<br>

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