上いん頭がんにおけるＥＢウイルス抗体価

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タイトル別名
  • Titers of EBV Antibody in Nasopharyngeal Carcinoma
  • ジョウ イントウガン ニ オケル EB ウィルス コウタイカ

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説明

It is considered that nonkeratinizing or undifferentiated squamous cell carcinoma in nasopharynx (NPC) is intimately correlated with Epstein-Barr Virus (EBV). 21 patients with NPC were followed in Kyoto University Hospital and 4 in Osaka red cross hospital during the past 2 years from 1980 to 1981. These patients were classified histopathologically according to WHO classification by Shanmugaratham in 1978 and staged with TNM classification in UICC in 1978.<br>The incidence rate of NPC among the head and neck tumor is 5.6% in our university from 1980 to 1981. The sex ratio of male to female is nearly equal. The stages of III and IV occupy 76% and both of nonkeratinizing and undifferentiated carcinoma predominate 84% of all NPC. The mean age of NPC patients is 56.7 years old.<br>Sera from these 25 patients with nasopharyngeal carcinoma were collected at intervals of 3 to 8 months over 2 years and examined for their spectra and titers of antibodies of EBV-related antigens. They were titrated for IgG, IgA and IgM antibodies to EB viral capsid antigen (VCA), for IgG and IgA antibodies to early antigen-DR component (EA) and for antibodies to EBV-associated nuclear antigen (EBNA).<br>All of these patients were primarily treated with radiation, a few of whom did not responded to this therapy and were subsequently treated with surgery or chemotherapy.<br>EBV antibodies of VCA-IgG, IgA, EA(DR)-IgG, IgA and EBNA were elevated in 73% and 90% of the nonkeratinizing or undifferentiated NPC patients respectively. That of VCA-IgM was never elevated in almost all the cases.<br>In contrast to this, those were all in a normal range in the NPC patients with keratinizing squamous cell carcinoma and malignant lymphoma. Also 9% and 10% of nonkeratinizing and undifferentiated carcinoma showed the normal ranges of EBV antibodies, possibly indicating the non-association with EBV.<br>When NPC disappeared with radiation therapy, EBV antibodies became normalized for 6-18 months. However, those whose NPC did not respond to the combined therapy with radiation, surgery and chemotherapy maintained the high titers of EBV antibodies.<br>The prognosis was the poorest in the patients with undifferentiated carcinoma, 40% of whom died within 4 years after the diagnosis.

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