高度難聴に対する内耳への薬物局所投与による臨床試験

DOI Web Site 参考文献11件
  • 伊藤 壽一
    京都大学大学院医学研究科耳鼻咽喉科・頭頸部外科

書誌事項

タイトル別名
  • Clinical Trial of Local Drug Application into the Inner Ear for Highly Hearing-Impaired Patients
  • コウド ナンチョウ ニ タイスル ナイジ エノ ヤクブツ キョクショ トウヨ ニ ヨル リンショウ シケン

この論文をさがす

抄録

There is no effective treatment for sensorinenral hearing disturbance. Inner ear sensory cells have been considered very fragile and functional recovery after damage is very difficult, making sensorinenral hearing loss very difficult to treat. Recently several drugs and chemicals have been reported to protect or promote recovery of inner ear function. However, applying those drugs to the inner ear is difficult because of specific anatomical and physiological factors. However, new technology using a drug delivery system (DDS) has introduced new possibilities. Especially, application of nerve growth factor in a biodegradable hydrogel is thought to be effective for protection and recovery of the inner ear function. We have reported the effectiveness of several drugs, especially nerve growth factors to prevent inner ear hair cell damage due to noise exposure or ototoxic chemicals in animals. We have begun a clinical trial using Insulin-like growth factor 1 (IGF-1) for the treatment of sudden deafness.

収録刊行物

参考文献 (11)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ