A Case Report of Primary Malignant Melanoma of the Nasopharynx
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- Waka Nobuhiko
- Rakusai Newtown Hospital, Kansai Medical University
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- Doi Tadashi
- Rakusai Newtown Hospital, Kansai Medical University Kansai Medical University
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- Iwai Hiroshi
- Rakusai Newtown Hospital, Kansai Medical University
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- Kawasaki Eiko
- Rakusai Newtown Hospital, Kansai Medical University
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- Baba Susumu
- Kansai Medical University
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- Nakae Kaori
- Kansai Medical University
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- Yamashita Toshio
- Kansai Medical University
Bibliographic Information
- Other Title
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- 上咽頭原発悪性黒色腫例
- リンショウ ジョウ イントウ ゲンパツ アクセイ コクショク シュレイ
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Abstract
Primary malignant melanoma of the nasopharynx is a rare disease with poor prognosis. There has been no established treatment for the disease.<br>We report herein a case of a 75-year old man, who was referred with hearing impairment and nasal obstruction. Clinical examination demonstrated left middle ear effusion and nasopharyngeal mass. The histological examination indicated malignant melanoma. Magnetic resonance imaging (MRI) showed a gadolinium-enhanced mass on the left side of nasopharynx. Imaging studies could not detect distant metastasis. The patient received combined chemotherapy with DAV treatment (DTIC+ACNU+VCR), but there was no response. Intratumoral administration of Interferon-beta inhibited tumor growth and X-knife was also effective in significantly decreasing tumor size. These therapies may be helpful in the local treatment of malignant melanoma, thus improving the patient's quality of life.
Journal
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- Practica Oto-Rhino-Laryngologica
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Practica Oto-Rhino-Laryngologica 97 (4), 307-312, 2004
The Society of Practical Otolaryngology
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Keywords
Details 詳細情報について
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- CRID
- 1390282679240614016
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- NII Article ID
- 10012846045
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- NII Book ID
- AN00107089
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- ISSN
- 18844545
- 00326313
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- NDL BIB ID
- 6909676
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed