書誌事項
- タイトル別名
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- The Conception of Mikulicz's Disease and Kuttner's Tumor (Chronic Sclerotic Sialadenitis) Based on New Knowledge
- ミクリッツビョウ ト キュットナー シュヨウ マンセイ コウカセイ ダエキセンエン ノ アタラシイ シッカン ガイネン
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抄録
The newly established concepts of Mikulicz's disease and Kuttner's tumor (chronic sialadenitis) are discussed. Mikulicz's disease has been included within the diagnosis of primary Sjogren's syndrome, but it represents a unique condition involving persistent enlargement of the lacrimal and salivary glands. Recently, elevated IgG4 concentration in serum and prominent infiltration by plasmacytes expressing IgG4 in the salivary glands was demonstrated in Mikulicz's disease. Mikulicz's disease differs from Sjogren's syndrome, and may be a systemic IgG4-related plasmacytic disease. Kuttner's tumor is a chronic sclerosing sialadenitis that presents with asymmetrical firm swelling of the submandibular glands. The histological characteristics of Kuttner's tumor are severe fibrosis, atrophic acinus, and mononuclear cell infiltration. Immunohistochemical evaluation demonstrated that the proportion of IgG4-positive plasmacytes was elevated in Kuttner's tumor similar to that in Mikulicz's disease. Therefore, it is possible that both Mikulicz's disease and Kuttner's tumor may involve a similar pathogenesis of IgG4-related disease as a form of autoimmune pancreatitis.
収録刊行物
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- 耳鼻咽喉科臨床
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耳鼻咽喉科臨床 101 (2), 73-82, 2008
耳鼻咽喉科臨床学会
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詳細情報 詳細情報について
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- CRID
- 1390282679240718464
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- NII論文ID
- 10021293824
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- NII書誌ID
- AN00107089
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- ISSN
- 18844545
- 00326313
- http://id.crossref.org/issn/00326313
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- NDL書誌ID
- 9362566
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可