Clinical Study of Levofloxacin (LVFX) 400 mg Orally in Two Divided Portions for Acute Exacerbation of Chronic Otitis Media and Chronic Sinusitis

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  • 中耳炎および副鼻腔炎に対するＬＶＦＸ（クラビット）の効果―１日４００ｍｇ分２投与の有用性―
  • ヤクブツ チュウジエン オヨビ フクビクウエン ニ タイスル LVFX クラビット ノ コウカ 1ニチ 400mg ブン 2 トウヨ ノ ユウヨウセイ
  • 1日400mg分2投与の有用性

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Twenty-six adult cases of acute exacerbation of chronic otitis media (COM) and twenty cases of acute exacerbation of chronic sinusitis (CS) were treated by Levofloxacin (LVFX) 400mg a day in two divided portions. The clinical efficacy rates were 84.6% for COM and 85% for CS. Bacteriolgical therapeutic failures in treatment were observed in four COM and three CS patients. Adverse response and abnormal laboratory findings were not observed. LVFX was more effective when given at 400mg a day in two divided portions.

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