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Effect of Serratiopeptidase on the Nasal Secretion from Patients with Chronic Sinusitis
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- Sakakura Yasuo
- Mie University
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- Majima Yuichi
- Mie University
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- Ohi Masuichi
- Mie University
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- Mitsui Hiroshi
- Mie University
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- Matsubara Takashi
- Mie University
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- Miyoshi Yasuro
- Mie University
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- Tomoda Katsumi
- Center Research Division Takeda Chemical
Bibliographic Information
- Other Title
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- 慢性副鼻こう炎鼻汁の研究 III セラチオペプチダーゼの影響
- マンセイ フクビクウエン ビジュウ ノ ケンキュウ 3 セラチオ ペプチダーゼ
- III. セラチオペプチダーゼの影響
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Description
The effect of serratiopeptidase (TSP), a representative proteolytic enzyme, on the nasal secretions from the patients with chronic sinusitis was studied. The patients were selected on the basis of rhinoscopy and radiology. Retained nasal secretion in the nasal cavity was carefully aspirated and diluted 8-fold with distilled water. Relative viscosity was measured by a method of the rate of the falling metal ball. Dry weight, amounts of protein and polysaccharide were determined before and every week during drug administration. TSP was given in a dose of 30mg/day orally for moret han four weeks.<br>In preadministration measurement, the mean relative viscosity, dry weight, amounts of protein and polysaccharide were 3.100±2.1810, 55.5mg/g±18.2, 29.9mg/g±18.8 and 3.3mg/g±1.9, respectively, and these were 2.6167±1.7836, 46.7mg/g±16.9, 24.3mg/g±19.4 and 2.7mg/g±1.5 at 4th week, respectively. The difference for the mean dry weight was significant (p<0.05). Although the mean relative viscosity, amounts of protein and polysaccharide tended to decrease by administration of TSP, the difference between preadministration and the 4th week was not significant.
Journal
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- Practica Oto-Rhino-Laryngologica
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Practica Oto-Rhino-Laryngologica 75 (3), 841-848, 1982
The Society of Practical Otolaryngology
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Keywords
Details 詳細情報について
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- CRID
- 1390282679241828224
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- NII Article ID
- 130001814051
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- NII Book ID
- AN00107089
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- ISSN
- 18844545
- 00326313
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- NDL BIB ID
- 2484883
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed