頭頸部悪性腫瘍患者における免疫機能の動態について

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  • Alternation of the Immune Response during Treatment of Cancer of the Head and Neck (Part 2)
  • トウケイブ アクセイ シュヨウ カンジャ ニ オケル メンエキ キノウ ノ ド
  • Changes in T lymphocyts in peripheral and local blood in patients with maxillary cancer
  • (第2報) 上顎癌患者の末梢血と局所血のTリンパ球の変動について

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The theory that cellular immunity may be the principal component of the defense mechanism against cancer in the living body is generally supported.<br>That T-cells play a leading role in this cellular immunity appears to be likewise supported.<br>However, the investigations previously performed by many authors have been done with T-cells from the peripheral blood. If immunity to cancer should exist, lymphocytes in the blood in cancerous tissue or tissue around the cancer (local blood) could possibly provide more pertinent information than that of peripheral blood. Thus, we compared T-cell values between blood obtained from tumor or tissue around the tumor at operation of the maxillary sinus (local blood) and peripheral blood in 15 cases with untreated maxillary cancer. As a result, the T-cell value in local blood was higher than that in peripheral blood, the difference being significant. In a similar study done on 16 patients with sinuitis, (controls), there was no difference between local and peripheral blood.<br>According to observations of eight patients with maxillary cancer, in whom local blood could be collected during the therapeutic course, there was a tendency for the difference in T-cell value between local blood and peripheral blood to decrease with the progress of the treatment in those in whom the tumor had regressed or disappeared.

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