ベルベリン型アルカロイドの行動薬理　Ｉ　　黄連ならびにその含有成分の中枢抑制作用

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  • 山原 條二
    岐阜大学医学部薬理学教室 京都薬科大学生薬学教室

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タイトル別名
  • Behavioral pharmacology of berberine-type alkaloids. (I) Central depressive action of Coptidis Rhizoma and its constituents
  • Berberineガタ アルカロイド ノ コウドウ ヤクリガクテキ ケンキュウ

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抄録

Coptis root is frequently utilized as a sedative in Chinese medicines, however, the central depressant action of this compound has not been reported. Such being the case, the central depressant actions of methanol extract of coptis root, its active ingredients such as non-alkaloids fraction, tertiary base fraction, quarternary base fraction, magnoflorine fraction, berberine hydrochloride, coptisine hydrochloride and the extract from SAN O SHA SHIN TO being one of the preparations which contain coptis root were investigated in mice. The antigastric ulcer action of these substances was also examined in rats. All substances were given orally. Spontaneous movement and coordinative motor activity were not depressed by methanol extract, non-alkaloid fraction, quarternary base fraction, magnoflorine fraction, berberine hydrochloride, coptisine hydrochloride and the extract from SAN O SHA SHIN TO. There was no inhibition of chemical and electroshock-induced convulsion, morphine induced Straub's tail reaction, apomorphine-induced masticating motion and aggressive behavior induced by electrical stimulation. A loss of righting reflex due to hypnotics was not potentiated by the substances. The quarternary base fraction did not elicit central depression, while the tertiary base fraction slightly depressed the function of the central nervous system. Quarternary base alkaloids such as berberine exerted a slight antiulcer effect.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 72 (7), 899-908, 1976

    公益社団法人 日本薬理学会

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