Ｎｉｃｅｒｇｏｌｉｎｅに関する薬理学的研究　ＩＩ　　虚血性脳障害に対する保護作用

DOI Web Site PubMed 被引用文献2件

書誌事項

タイトル別名
  • Pharmacological study of nicergoline. II. Protective effect on ischemic brain damages in animals.
  • Nicergoline ニ カンスル ヤクリガクテキ ケンキュウ 2 キョケツ
  • Protective effect on ischemic brain damages in animals
  • 虚血性脳障害に対する保護作用

この論文をさがす

抄録

Effects of nicergoline on ischemic brain damages induced by bilateral carotid arterial ligation (BCAL) in ICR-strain mice and mongolian gerbils and lipid peroxide formation (LPOF) in normal brain homogenate of rats were compared with those of dihydroergotoxine (DHE). In mice, nicergoline(16 mg/kg, i.p.) significantly reduced the cumulative mortality rate after BCAL (from 80 ?? 83% in the control to 50 ?? 55%). In gerbils, nicergoline (32 mg/kg, i.p.)significantly prolonged the mean onset time of ischemic seizure following recirculation after the 30-min BCAL (from 45.8 min in the control to 94.9 min). DHE also showed protective effects in these animals. In the ischemic brain of mice, marked decreases of creatine-P, ATP, glucose and glycogen; a remarkable increase of lactate; and elevation of L/P ratio were observed 1 to 10 min after BCAL. Nicergoline (16 mg/kg, i.p.) slightly prevented these decreases and significantly suppressed the increase of lactate and the elevation of L/P ratio 2 min after BCAL. The inhibitory action of nicergoline (20 ?? 100 μM) on LPOF is more potent than those of α-tocopherol and DHE. These results suggest that nicergoline may have protective effects against ischemic brain damages due to its ameliorating action on cerebral energy metabolism and partially due to its inhibitory action of LPOF.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 87 (4), 427-434, 1986

    公益社団法人 日本薬理学会

被引用文献 (2)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ