Pharmacological study of nicergoline. II. Protective effect on ischemic brain damages in animals.

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  • SHINTOMI Keiichi
    Department of Pharmacology and Biochemistry, Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
  • ITAKURA Tadashi
    Department of Pharmacology and Biochemistry, Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
  • YOSHIMOTO Kenichi
    Department of Pharmacology and Biochemistry, Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
  • OGAWA Youri
    Department of Pharmacology and Biochemistry, Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
  • FUKUSHIMA Tomiko
    Department of Pharmacology and Biochemistry, Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.
  • MATSUOKA Yuzo
    Department of Pharmacology and Biochemistry, Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.

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Other Title
  • Ｎｉｃｅｒｇｏｌｉｎｅに関する薬理学的研究　ＩＩ　　虚血性脳障害に対する保護作用
  • Nicergoline ニ カンスル ヤクリガクテキ ケンキュウ 2 キョケツ
  • Protective effect on ischemic brain damages in animals
  • 虚血性脳障害に対する保護作用

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Abstract

Effects of nicergoline on ischemic brain damages induced by bilateral carotid arterial ligation (BCAL) in ICR-strain mice and mongolian gerbils and lipid peroxide formation (LPOF) in normal brain homogenate of rats were compared with those of dihydroergotoxine (DHE). In mice, nicergoline(16 mg/kg, i.p.) significantly reduced the cumulative mortality rate after BCAL (from 80 ?? 83% in the control to 50 ?? 55%). In gerbils, nicergoline (32 mg/kg, i.p.)significantly prolonged the mean onset time of ischemic seizure following recirculation after the 30-min BCAL (from 45.8 min in the control to 94.9 min). DHE also showed protective effects in these animals. In the ischemic brain of mice, marked decreases of creatine-P, ATP, glucose and glycogen; a remarkable increase of lactate; and elevation of L/P ratio were observed 1 to 10 min after BCAL. Nicergoline (16 mg/kg, i.p.) slightly prevented these decreases and significantly suppressed the increase of lactate and the elevation of L/P ratio 2 min after BCAL. The inhibitory action of nicergoline (20 ?? 100 μM) on LPOF is more potent than those of α-tocopherol and DHE. These results suggest that nicergoline may have protective effects against ischemic brain damages due to its ameliorating action on cerebral energy metabolism and partially due to its inhibitory action of LPOF.

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