ラット子宮におけるプロスタグランジン（Ｉ）ＦおよびＥの相互変換に対する卵胞ホルモン（ＩＩ）の作用

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タイトル別名
  • Effect of estrogen on interconversion of prostaglandin F and E in rat uterus
  • ラット シキュウ ニ オケル Prostaglandin F オヨビ E ノ

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To determine estrogen action in PG metabolism in rat uterus, effect of the hormone on the uptake and interconversion of PGF and E was studied using 3H-PGFα and 3H-PGE2. The following results were obtained: Uptake of 3H-PGFα and 3H-PGE2 was increased at 6 hours after estrogen injection. The conversion into PGF and PGE group from 3H-PGE2 and 3H-PGF2α, respectively, was observed in rat uterus, but the hormone action on the interconversion of PG was apparently different between PGF2α and PGE2. The conversion of 3H-PGF2α into PGE group was increased with the lapse of time after estrogen injection. However, estrogen action on the conversion of 3H-PGE2 into PGF group was not so remarkable as that of 3H-PGF2α. Effects of indomethacin in vivo and in vitro on the metabolism of PGF2α. increased by estrogen were also examined. Estrogen action on the uptake of PGF group was inhibited by indomethacin injection, but the conversion into PGE was not influenced by this compound.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 73 (8), 871-876, 1977

    公益社団法人 日本薬理学会

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