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    • ヒト尿中Ｔｒｙｐｓｉｎ　ｉｎｈｉｂｉｔｏｒの実験的急性すい炎に対する効果　Ｉ

    DOI Web Site PubMed 被引用文献9件

    書誌事項

    タイトル別名
    • Therapeutic effects of human urinary trypsin inhibitor on acute experimental pancreatitis
    • ヒト ニョウチュウ Trypsin inhibitor ノ ジッケンテキ キュ
    公開日
    1983
    資源種別
    journal article
    DOI
    • 10.1254/fpj.81.235
    公開者
    公益社団法人 日本薬理学会

    この論文をさがす

    説明

    Therapeutic effects of human urinary trypsin inhibitor (MTI) on acute pancreatitis were examined. MTI potently inhibited not only proteases such as trypsin or α-chymotrypsin, but also inhibited lipase or creatine phosphokinase which are considered to be related to pancreatitis. Although gabexate mesilate (gabexate) and aprotinin also strongly inhibited trypsin, their inhibition spectra against pancreatic enzymes were narrower than MTI. MTI inhibited proteases released from pancreatic slice by trypsin more potently than gabexate or aprotinin. The therapeutic effects of MTI on experimental acute trypsin-induced pancreatitis in dogs or rats were stronger than those of gabxate or aprotinin. These results suggest that MTI may suppress pathogenesis and development of pancreatitis in several ways, for example, by directly inhibiting trypsin and by inhibiting tissue-damaging enzymes released from the pancreas by stimulation with trypsin.

    収録刊行物

    • 日本薬理学雑誌

      日本薬理学雑誌 81 (3), 235-244, 1983

      公益社団法人 日本薬理学会

    被引用文献 (9)*注記

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