書誌事項
- タイトル別名
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- Effects of NIK-247 on the spontaneous EEG of normal and nucleus basalis magnocellularis lesioned rats.
- シンキ コウ チホウヤク NIK-247 ノ セイジョウ オヨビ キテイカク
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説明
Effects of oral administration of NIK-247 (9-amino-2, 3, 5, 6, 7, 8-hexahydro-1H-cyclopenta-[b]quinoline monohydrochloride monohydrate) and THA (9-amino-1, 2, 3, 4-tetrahydroacridine hydrochloride hydrate) on the EEG of normal and nucleus basalis magnocellularis (NBM) lesioned rats were examined. NIK-247 at 1mg /kg and 3 mg/kg did not show any effects on the EEG of normal rats, but NIK-247 at 10 mg/kg significantly lowered the total power of the cortical EEG in normal rats. THA at 3 mg/kg and 10 mg/kg also decreased the total power of cortical EEG in normal rats. In the NBM-lesioned rats, decreases of delta wave activity as well as the total power of cortical EEG were observed with both NIK-247 and THA at 3 mg/kg, respectively. The arousal effects of these two drugs were comparable to the effect of physostigmine, suggesting the central cholinergic effects of both NIK-247 and THA.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 104 (2), 111-120, 1994
公益社団法人 日本薬理学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679247957888
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- NII論文ID
- 130000759702
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- NII書誌ID
- AN00198335
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 3898545
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- PubMed
- 7927068
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可