Development of a new delayed healing model of an open skin wound and effects of M-1011G(ointment gauze containing 5% lysozyme hydrochloride) on the model.

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  • 新しい創傷治癒遅延モデルの開発とそのモデルに対する塩化リゾチーム軟膏ガーゼ（Ｍ‐１０１１Ｇ）の効果
  • アタラシイ ソウショウ チユ チエン モデル ノ カイハツ ト ソノ モデル

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We tried to develop a new delayed healing model of an open wound made on the dorsal skin of a rat by inducing malnutrition with restriction of food intake. We determined the effects of a newly introduced ointment gauze containing 5% lysozyme hydrochloride (M-1011G) on this model. Malnutrition characterized by a decrease in body weight and serum protein was produced by restricting the daily intake of commercially avail able food to 6 g for 2 weeks without liver disturbance and thereafter maintained with food intake of 12 g/day. Under these conditions, healing of the open wound made on the dorsal skin was prolonged, as compared with that of the wound made on a well-nourished animal. In this model, statistical studies showed that M-1011G was the most effective in accelerating the reduction of the wound area and shortening of the time required for the complete healing, among the following treatments: sterilized gauze alone, ointment gauze alone and 5% lysozyme hydrochloride-containing emulsified ointment. Histological findings showed that M-1011G greatly accelerated the granulation of this tissue which is essential for wound healing, probably due to stimulation of epidermization and regenerated granulation in the wound.

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