Pharmacological profile and clinical effect of zolpidem (Myslee tablets), a hypnotic agent.

DOI Web Site PubMed 5 Citations 48 References

Bibliographic Information

Other Title
  • 睡眠薬酒石酸ゾルピデム（マイスリー錠）の薬理学的特性と臨床効果
  • 新薬紹介総説 睡眠薬酒石酸ゾルビデム(マイスリー錠)の薬理学的特性と臨床効果
  • シンヤク ショウカイ ソウセツ スイミンヤク シュセキサン ゾルビデム マイスリージョウ ノ ヤクリガクテキ トクセイ ト リンショウ コウカ

Search this article

Description

Zolpidem is a non-benzodiazepine hypnotic agent with a chemical structure of imidazopyridine. In vitro and in vivo binding studies, zolpidem exhibits selectivity to ω1 receptors (GABAA-receptor subtypes containing α1 subunits). Unlike benzodiazepines, zolpidem produces sedative effects in preference to anxiolytic, anticonvulsant and myorelaxant effects in behavioral experiments using mice. Double-blind comparative studies with reference drugs such as triazolam and zopiclone show that zolpidem is an effective and highly safe drug for the treatment of insomnia. In addition, zolpidem does not produce next-day residual effects, rebound insomnia and tolerance. This clinical profile of zolpidem may be related to its selectivity and high intrinsic activity for ω1 receptors.<br>

Journal

Citations (5)*help

See more

References(48)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top