Lithium塩の薬理学的研究(第3報)　―塩化リチウム(LiCl)の循環系および平滑筋におよぼす一般薬理作用―

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  • Pharmacological studies of lithium salts. III. General pharmacological actions of LiCI on cardiovascular system and smooth muscles
  • Lithiumエン ノ ヤクリガクテキ ケンキュウ 3 エンカ リチウム LiCl ノ ジュンカンケイ オヨビ ヘイカツキン ニ オヨボス イッパン ヤクリ サヨウ

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説明

LiCl caused a temporary fall followed by a continuous rise on blood pressure in rat, cat and dog. The temporary fall on blood pressure was not suppressed by atropine, propranolol, diphenhydramine and vagotomy. The continuous rise was suppressed by phentolamine, hexamethonium, chlorpromazine, reserpine and pithed treatment, and only a temporary rise was observed. Also, LiCl potentiated the effects of norepinephrine and tyramine on blood pressure. Furthermore, LiCl resulted in an increased action of cardiac force and output, and a dilative action of peripheral vessels. On the other hand, LiCl had no effect on smooth muscle preparations. From these results, it is concluded that LiCl in a relatively high dose influences the circulatory system through a central action as well as direct action on the peripheral vessels and the heart muscle.

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  • 日本薬理学雑誌

    日本薬理学雑誌 70 (2), 215-230, 1974

    公益社団法人 日本薬理学会

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