Effect of suloctidil on cerebral venous outflow in the dog

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  • Ｓｕｌｏｃｔｉｄｉｌの脳静脈血流出量に及ぼす作用
  • Suloctidil ノ ノウ ジョウミャクケツ リュウシュツリョウ ニ オヨ

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The effects of intravenous administration of suloctidil [erythro-1-(4-isopropylthiophenyl)-2-n-octylaminopropanol], (MY 103) on cerebral venous outflow (VOF), blood gases, cerebral metabolic rate of oxygen (CMRO2) and other hemodynamic parameters were studied and effects compared to those of cinnarizine and papaverine, in gallamine immobilized dogs. MY 103 and papaverine at doses 0.1_??_1.0mg/kg, i. v. caused significant increases in VOF by 6.1_??_38.3% and 12.1_??_26.1%, respectively. The changes in VOF persisted for 1.4min and 0.5min in mean following 1.0mg/kg, i. v. of MY 103 and papaverine, respectively. Cinnarizine also increased VOF by 10.0 and 18.7% at doses 0.3 and 1.0mg/kg, i. v.. The duration of VOF changes by cinnarizine 1.0mg/kg, i. v., 2.4min (mean), was longer than the duration seen with the same dose of MY 103 or papaverine. Mean blood pressure (MBP) decreased dose dependently with these drugs and consequently the cerebral vascular resistance (CVR) decreased by 8.6_??_40.2% with MY 103, 13.6_??_25.0% with cinnarizine and 16.1_??_39.5% with papaverine administration, respectively. MY 103 and papaverine at a dose of 1.0mg/kg, i. v. did not affect pH, Pco2 and Po2 in arterial blood, but these two drugs did show a tendency to lower Pco2 and elevate Po2 in cerebral venous blood. CMRO2 was not significantly affected by MY 103 or papaverine. It is suggested that cerebral vasodilation may be the mechanism for VOF increase following MY 103 administration.

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