Effects of flutropium bromide, a new antiasthma drug, on mediator release from mast cells and actions of mediators.
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- MISAWA Miwa
- Department of Applied Pharmacology, School of Pharmacy, Hoshi University
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- YANAURA Saizo
- Department of Applied Pharmacology, School of Pharmacy, Hoshi University
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- HOSOKAWA Tomokazu
- Department of Pharmacology School of Pharmacy, Hoshi University
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- MIZUNO Hiroyuki
- Central Research Laboratory, SS Pharmaceutical Co., Ltd.
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- IRINODA Kazuhiko
- Central Research Laboratory, SS Pharmaceutical Co., Ltd.
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- TAKAHASHI Yoshinori
- Central Research Laboratory, SS Pharmaceutical Co., Ltd.
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- YOSHIMURA Keiji
- Central Research Laboratory, SS Pharmaceutical Co., Ltd.
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- MARUYAMA Youko
- Central Research Laboratory, SS Pharmaceutical Co., Ltd.
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- SUGIMOTO Kiyomi
- Central Research Laboratory, SS Pharmaceutical Co., Ltd.
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- OHNO Hiromitsu
- Central Research Laboratory, SS Pharmaceutical Co., Ltd.
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- KUWAMURA Tukasa
- Central Research Laboratory, SS Pharmaceutical Co., Ltd.
Bibliographic Information
- Other Title
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- 新規抗ぜん息薬Flutropium bromideのMediator遊離抑制作用及びMediatorきっ抗作用
- シンキ コウ ゼンソクヤク Flutropium bromide ノ Medi
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Abstract
The effects of flutropium bromide (Ba598Br), a new antiasthma drug possessing the quarternary ammonium structure of atropine derivatives, on mediator release from mast cells and on actions of leukotriene (LT) D4 and serotonin were investigated. Flutropium bromide (3 and 10 mg/kg, i.v.) showed an inhibitory action on the 48 hr homologous PCA in guinea pigs. Atropine showed no inhibitory effect. Flutropium bromide also inhibited the release of histamine from isolated rat mast cells stimulated by antigen, although the inhibitory action was weaker than that of disodium cromoglycate. Atropine also had no inhibitory action in this case. Flutropium bromide and atropine showed no antagonistic action against LTD4-induced contraction of isolated tracheal smooth muscle of guinea pigs. Inhalation of flutropium bromide (0.3%) also showed no antagonistic action against serotonin-induced bronchoconstriction in dogs. From the above results, it is indicated that flutropium bromide has a weak mast cell stabilizing action, but no antagonistic action against LTD4 and serotonin.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 91 (2), 97-103, 1988
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679248256768
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- NII Article ID
- 130000759399
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaL1cXht1Chsrw%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 3175364
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- PubMed
- 2453423
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed