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- 尾崎 幸紘
- 国立衛生試験所生薬部
書誌事項
- タイトル別名
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- Vasodilative effects of indole alkaloids obtained from domestic plants, Uncaria rhynchophylla Miq. and Amsonia elliptica Roem. et Schult.
- ホンポウサン ショクブツ カギカズラ オヨビ チョウジソウ ガンユウ インドー
この論文をさがす
説明
Vasodilative effects of hirsutine (HS) and hirsuteine (HST) which were isolated from the domestic plant Uncaria rhynchophylla MiQ. and β-yohimbine (β-Y) which was isolated from the domestic plant Amsonia elliptica ROEM. et SCHULT. were carried out. In the hind-limb artery of anesthetized dogs, intra-arterial administration of HS, HST and β-Y caused a vasodilatation. The vasodilative potency of HS was somewhat stronger than that of HST, and the potency of both alkaloids was approximately equal to that of papaverine. The vasodilative effect of β-Y was similar to that of yohimbine, which is considered to be derived from its α-adrenoceptor blocking effect, and the potency of both alkaloids was approximately the same, while the effect of β-Y was stronger than that of papaverine. In the coronary artery, HS showed a vasodilatation and its potency was weaker than that of papaverine. Also, HS showed the same effect in the cerebral artery, and the potency of HS was approximately the same as that of papaverine. These results suggest that the mode of the vasodilative effect induced by HS may partly differ from that of papaverine.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 95 (2), 47-54, 1990
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679248288256
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- NII論文ID
- 30034986541
- 130000759100
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaK3cXhslajuro%3D
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- ISSN
- 13478397
- 00155691
- http://id.crossref.org/issn/00155691
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- NDL書誌ID
- 3659478
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- PubMed
- 2328929
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可