本邦産植物カギカズラおよびチョウジソウ含有インドールアルカロイドの血管拡張作用

DOI Web Site PubMed 被引用文献3件

書誌事項

タイトル別名
  • Vasodilative effects of indole alkaloids obtained from domestic plants, Uncaria rhynchophylla Miq. and Amsonia elliptica Roem. et Schult.
  • ホンポウサン ショクブツ カギカズラ オヨビ チョウジソウ ガンユウ インドー

この論文をさがす

説明

Vasodilative effects of hirsutine (HS) and hirsuteine (HST) which were isolated from the domestic plant Uncaria rhynchophylla MiQ. and β-yohimbine (β-Y) which was isolated from the domestic plant Amsonia elliptica ROEM. et SCHULT. were carried out. In the hind-limb artery of anesthetized dogs, intra-arterial administration of HS, HST and β-Y caused a vasodilatation. The vasodilative potency of HS was somewhat stronger than that of HST, and the potency of both alkaloids was approximately equal to that of papaverine. The vasodilative effect of β-Y was similar to that of yohimbine, which is considered to be derived from its α-adrenoceptor blocking effect, and the potency of both alkaloids was approximately the same, while the effect of β-Y was stronger than that of papaverine. In the coronary artery, HS showed a vasodilatation and its potency was weaker than that of papaverine. Also, HS showed the same effect in the cerebral artery, and the potency of HS was approximately the same as that of papaverine. These results suggest that the mode of the vasodilative effect induced by HS may partly differ from that of papaverine.

収録刊行物

被引用文献 (3)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ