Effects of lithium chloride administered in combination with methamphetamine or a reserpine-like drug on brain norepinephrine and dopamine metabolism in rats

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  • ラット脳におけるノルエピネフリン（ＮＥ）・ドーパミン（ＤＡ）代謝に対するメタンフェタミン（Ｉ）ならびにレセルピン（ＩＩ）類似薬併用下でのリチウム塩の作用
  • ラット ノウ ニ オケル Norepinephrine ・ Dopamine タイシャ ニ タイスル Methamphetamine ナラビニ Reserpine ルイジヤク ヘイヨウ カ デ ノ Lithiumエン ノ サヨウ

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Abstract

Lithium chloride (LiCI) was injected acutely (2.4 mEq/kg, i.p.) or subacutely (2.5 mEq/kg × 2/day for 4.5 days, i.p.) in rats treated concurrently with methamphetamine (MAPT) or a reserpine-like drug (Ro4-1284), and effects of LiCI on behavior as well as metabolism of brain norepinephrine (NE) and dopamine (DA) were investigated. Acute administration of LiCl suppressed the MAPT-induced hyper-locomotor activity but did not affect the Ro4-1284-induced behavioral depression. LiC1 administered subacutely increased the MAPT-induced stereotyped behavior, and it reduced the Ro4-1284-induced initial transient excitation in spontaneous locomotor activity and tended to facilitate the recovery from behavioral depression. As for NE and DA metabolism, LiCI administered subacutely inhibited the MAPT-induced decrease of the deaminated NE metabolites and Ro4-1284-induced decrease of DA contents, though it did not affect significantly the MAPT-induced changes in DA metabolism and the Ro4-1284-induced alterations in NE metabolism. From these results, it is likely that the inhibitory effect of LiCl on the MAPT and Ro-1284-induced changes in NE and DA metabolism may to some extent be involved in the therapeutic effects on manic-depressive illness.

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