Effect of benzodiazepines on penicillin induced epileptic discharges

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  • TSUCHIYA Toshiro
    Research and Development Center, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd
  • FUKUSHIMA Hideaki
    Research and Development Center, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd
  • KITAGAWA Sumio
    Research and Development Center, Pharmaceuticals Division, Sumitomo Chemical Co., Ltd

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Other Title
  • ペニシリン誘発性けいれんに対するベンゾジアゼピン系化合物の抑制作用
  • Penicillin ユウハツセイ ケイレン ニ タイスル Benzodiaz

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Abstract

Effects of clonazepam, nitrazepam and diazepam on penicillin induced primary, spread and reactive epileptoform discharges were investigated in gallamine immobilized cats. Different strengths of seizure foci were induced by penicillin G 1000, 3000 and 6000 U injected into the cortex, amygdala and intralaminal thalamus, and the spread of epileptic discharges in the subcortex or surrounding area and to the contralateral area was followed. Benzodiazepines 5 mg/kg i.v. shortened the duration of primary epileptoform discharges and prolonged the interictal interval in the cortical, amygdaloid and intralarinal thalamic epileptogenesis induced by a high concentration of penicillin G. When a low concentration of penicillin G was injected into the cortex, amygdala and intralaminal thalamus, benzodiazepines abolished the spread of primary epileptoform discharges and the reactive discharges, but did not suppress completely the primary epileptogenic discharges and the contralateral reflective activity. Suppression of the discharges necessitated administration of a high dose. The greatest degree of suppression was seen with clonazepam. It is concluded that the anticonvulsive effect of benzodiazepines may be due to the blockades of neuronal pathways which spread the seizure discharges from the site of origin (focus) to the effector organ, and the elevation of convulsive thresholds.

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