Effects of benzodiazepines, MS4101, on emotional behaviour in untamed cats

DOI Web Site PubMed
  • ANEZAKI Ken
    Department of Chemical Pharmacology, Tohoku College of Pharmacy
  • SAKURADA Shinobu
    Department of Chemical Pharmacology, Tohoku College of Pharmacy
  • ANDO Ryuichiro
    Department of Chemical Pharmacology, Tohoku College of Pharmacy
  • KISARA Kensuke
    Department of Chemical Pharmacology, Tohoku College of Pharmacy
  • NAKAHAMA Hiroshi
    Division of Neurophysiology, Institute of Brain Diseases, Tohoku University School of Medicine

Bibliographic Information

Other Title
  • 人なれしてないネコの情動行動に及ぼすベンゾジアゼピン誘導体ＭＳ４１０１の影響
  • Untamed cats ノ ジョウドウ コウドウ ニ オヨボス Benzod

Search this article

Abstract

Effects of MS4101 on emotional behaviour in untamed cats were studied and compared with those of diazepam. Offensive behaviour, i.e., whine response to a rod presented in front of the snout and blowing air on back hair was markedly observed, and whine, attacking and biting responses to tapping with a rod on the back in these cats were marked. Defensive behaviour, i.e., hissing, crouching body, ear flattening to blowing air on back hair, a rod presented and tapping was markedly observed. From 30 min after MS4101 and diazepam in doses of 2 ?? 4 mg/kg i.p., offensive behaviour in untamed cats was depressed. ID50 (50% of inhibition dose) of offensive behaviour for MS4101 and diazepam was 2.40 (1.95 ?? 2.95) mg/kg i.p. and 0.96 (0.69 ?? 1.34) mg/kg i.p., respectively. MS4101 and diazepam in doses of 2 ?? 4 mg/kg i.p. decreased the offensive behaviour. ID50 of defensive behaviour for MS4101 and diazepam was 3.00 (2.46 ?? 3.66) mg/kg i.p. and 1.45 (1.14 ?? 1.84) mg/kg i.p., respectively. Both MS4101 and diazepam exhibited muscle relaxant effects. Here, diazepam was more effective than MS4101. ED50 of muscle relaxant activity for MS4101 and diazepam was 4.30 (3.03 ?? 6.11) mg/kg i.p., 7.40 (5.04 ?? 10.66) mg/kg i.p., respectively. A single administration of MS4101 and of diazepam in doses 2 mg/kg i.p. enhanced food intake.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top