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- UEKI Showa
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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- YAMAMOTO Tsuneyuki
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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- SHIMAZOE Takao
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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- SHIBATA Shigenobu
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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- TANI Yoshihiro
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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- MACHIDA Koichi
- NIPPON SHOJI KAISHA, LTD.
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- HOJO Masakazu
- NIPPON SHOJI KAISHA, LTD.
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- YOSHIDA Yoichi
- NIPPON SHOJI KAISHA, LTD.
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- TATSUMI Hiroshi
- NIPPON SHOJI KAISHA, LTD.
Bibliographic Information
- Other Title
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- 新しい抗うつ薬Quinupramineの行動薬理学的研究
- アタラシイ コウ ウツヤク Quinupramine ノ コウドウ ヤクリガク
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Abstract
The effects of a new tricyclic antidepressant quinupramine (5-(3-quinuclidinyl)-10, 11-dihydro-5H-dibenz [b, f] azepine) on various animal behaviors were examined in mice and rats and compared with those of imipramine, amitriptyline and maprotiline. Quinupramine antagonized haloperidol-induced catalepsy and tetrabenazine-induced ptosis and potentiated methamphetamine- and apomorphine-induced stereotyped behavior. These effects were almost the same as or even more potent than those of imipramine and amitriptyline. Quinupramine decreased locomotor activity in mice, but potentiated methamphetamine-induced hyperactivity to a greater degree than imipramine and amitriptyline. On the other hand, quinupramine inhibited muricide in accumbens-lesioned rats, but did not prominently inhibit muricide in olfactory-bulbectomized and raphe-lesioned rats. Quinupramine decreased the duration of immobility in low doses without affecting locomotor activity, and this effect was almost the same as that of imipramine and amitriptyline and more potent than that of maprotiline. Quinupramine antagonized physostigmine lethality and oxotremorine-induced tremor, suggesting that quinupramine has a central anticholinergic action. Quinupramine, like imipramine and amitriptyline, has no effect on conditioned avoidance behavior. In conclusion, quinupramine generally has the same behavioral profile as typical tricyclic antidepressants, but it has somewhat different effects from imipramine and amitriptyline since quinupramine has a potent central anticholinergic and a weak antimuricide effect.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 91 (6), 359-369, 1988
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679248490240
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- NII Article ID
- 130000759365
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaL1cXktlajtrw%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 3188675
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- PubMed
- 3417209
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed