Effects of β-(p-chlorophenyl)-GABA (baclofen) on response to noxious stimuli.
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- YAMAMOTO Hiroyuki
- Department of Pharmacology, Wakayama Medical College
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- KUKI Motoo
- Department of Pharmacology, Wakayama Medical College
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- OZAKI Masanobu
- Department of Pharmacology, Wakayama Medical College
Bibliographic Information
- Other Title
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- β‐(p‐クロロフェニル)‐GABA(バクロフェン)の侵害刺激反応に対する影響
- ベータ p Chlorophenyl GABA baclofen ノ シンガイ
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Abstract
Effects of β-(p-chlorophenyl)-GABA (baclofen), a muscle relaxant, on the response of mice and rats to various noxious stimuli were studied. In mice, 5 ?? 10 mg/kg i.p. of baclofen delayed the response time to tail-pinch and hot-plate stimuli but the relaxation was also apparent with this dose range. Mephenesin also delayed the response time to tail-pinch stimuli with the dose producing muscle relaxation. Baclofen, 3 mg/kg i.p., while producing no muscle relaxation, suppressed the acetic acid-induced writhing. The same effect, suppression of writhing and no muscle relaxation, was achieved with 50 mg/kg i.p. of mephenesin. In rats, baclofen (5 ?? 10 mg/kg i.p.) increased the response threshold in Randall-Selitto method and suppressed the bradykinininduced symptoms, however, muscle relaxation was also produced with these same doses. Increase in response threshold in Randall-Selitto method was achieved with the dose of mephenesin producing muscle relaxation. The time courses of the depression of response to noxious stimuli and the muscle relaxation induced by baclofen and mephenesin were consistent in mice and rats. A small dose (3 mg/kg i.p. in mice, 2 mg/kg/h s.c. in rats) of baclofen reduced the antinociceptive effect of morphine but a larger dose (5 mg/kg i.p. in mice, 7 mg/kg/h s.c. in rats) of baclofen increased or did not alter the effect of morphine. It seems likely that the antinociceptive effect of baclofen may be nonspecific to analgesia.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 73 (7), 703-715, 1977
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679248521216
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- NII Article ID
- 130000758831
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaE1cXpvFShsQ%3D%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 1914448
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- PubMed
- 598782
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed