Functional involvement of cerebral diazepam inhibitor(DBI) in the establishment of drug dependence.
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- KATSURA Masashi
- Department of Pharmacology, Kawasaki Medical School
Bibliographic Information
- Other Title
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- 薬物依存形成に伴う脳内diazepam binding inhibitor(DBI)の機能的変化とその意義
- 受賞者講演 薬物依存形成に伴う脳内diazepam binding inhibitor(DBI)の機能的変化とその意義
- ジュショウシャ コウエン ヤクブツ イゾン ケイセイ ニ トモナウ ノウナイ diazepam binding inhibitor DBI ノ キノウテキ ヘンカ ト ソノ イギ
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Description
Mechanisms for formation of drug dependence and emergence of withdrawal syndrome are not yet fully understood despite of a huge accumulation of experimental and clinical data. Several clinical features of withdrawal syndrome are considered to be common (i.e., anxiety) among patients with drug dependence induced by different drugs of abuse. In this review, we have discussed the possibility of the functional involvement of diazepam binding inhibitor (DBI), an endogeneous neuropeptide for benzodiazepine receptors with endogenously anxiogenic potential, in the development of drug dependence and emergence of its withdrawal symptom. The levels of DBI protein and its mRNA significantly increased in the brain derived from mice dependent on alcohol (ethanol), nicotine and morphine, and abrupt cessation of these drugs facilitated further increase in DBI expression. In the cases of nicotine- and morphine-dependent mice, concomitant administration of antagonists for nicotinic acetylcholine and opioid receptors, respectively, abolished the increase in DBI expression. Therefore, these alterations in DBI expression have a close relationship with formation of drug dependence and/or emergence of withdrawal syndrome and are considered to be a common biochemical process in drug dependence induced by different drugs of abuse.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 117 (3), 159-168, 2001
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679248565248
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- NII Article ID
- 10007365689
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DC%2BD3MXisFGquro%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 5685167
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- PubMed
- 11288485
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed