A Case of IgG4-related Disease in the Sinus and Nasal Cavity

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  • 鼻副鼻腔病変より診断されたIgG4関連疾患例
  • 臨床 鼻副鼻腔病変より診断されたIgG4関連疾患例
  • リンショウ ハナ フクビコウ ビョウヘン ヨリ シンダン サレタ IgG4 カンレン シッカンレイ

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Abstract

IgG4-related disease appears in multiple organs, such as the salivary gland, pancreas, bile duct, and retroperitoneum. It shows elevated serum IgG4 and histopathological IgG4-positive plasma cell infiltration. We report a case of IgG4-related disease of the sinus and nasal cavity. A 70-year-old man complained of left nasal obstruction and nasal bleeding. Computed tomography showed a mass with bone destruction of the left inferior nasal concha and maxillary sinus. Biopsy findings were consistent with IgG4-positive plasma cell infiltration and serum IgG4 was elevated. Inhalation-steroid therapy was very effective in this case with symptoms and local findings relieved in a few months. About 2 years later, the serum IgG4 level had normalized. We concluded that inhalation-steroid therapy was useful in treating for IgG4-related disease of the sinus and nasal cavity, serving as index of curative effect.<br>

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