Effects of triazolam on conditioned behavior in rats

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  • GOMITA Yutaka
    Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
  • GOMITA Hiroko
    Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
  • NAKAEBISU Hatsumi
    Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
  • KATAOKA Yasufumi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
  • UEKI Showa
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University

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Other Title
  • ベンゾジアゼピン誘導体トリアゾラムの条件行動に対する作用
  • Benzodiazepine ユウドウタイ Triazolam ノ ジョウケン

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Effects of triazolam on various types of conditioned behavior were investigated and compared mainly with diazepam in rats. The active conditioned avoidance response of the rat in a Shuttle box was inhibited by triazolam and diazepam only at large doses. The passive avoidance response in a step-down method was not affected by either triazolam or diazepam, but was markedly suppressed by chlorpromazine. The low rate response of hypothalamic self-stimulation behavior was markedly increased by triazolam at doses ranging from 2 to 40 mg/kg p.o., but was suppressed at doses over 80 mg/kg p.o. The high rate response was unaffected by triazolam even at doses of 40 ?? 180 mg/kg p.o. The low rate response was increased by diazepam at doses of 1 ?? 10 mg/kg p.o. and was suppressed at 80 mg/kg p.o. The high rate response was reduced by diazepam at 180 mg/kg p.o. In the conflict situation of the rat subjected to food reward and foot-shock punishment, the lever press response in the unpunished period was reduced by triazolam at doses of 1 ?? 5 mg/ kg p.o., whereas that in the punished period was markedly increased. Similar effects were observed with diazepam at doses of 15 ?? 20 mg/kg p.o. Triazolam appeared to be 10 ?? 15 times more potent than diazepam in this anticonflict effect. Thus, triazolam appears to be a potent antianxiety agent.

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