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Effects of triazolam on conditioned behavior in rats
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- GOMITA Yutaka
- Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
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- GOMITA Hiroko
- Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
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- NAKAEBISU Hatsumi
- Department of Pharmacology, Daiichi College of Pharmaceutical Sciences
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- KATAOKA Yasufumi
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
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- UEKI Showa
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University
Bibliographic Information
- Other Title
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- ベンゾジアゼピン誘導体トリアゾラムの条件行動に対する作用
- Benzodiazepine ユウドウタイ Triazolam ノ ジョウケン
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Description
Effects of triazolam on various types of conditioned behavior were investigated and compared mainly with diazepam in rats. The active conditioned avoidance response of the rat in a Shuttle box was inhibited by triazolam and diazepam only at large doses. The passive avoidance response in a step-down method was not affected by either triazolam or diazepam, but was markedly suppressed by chlorpromazine. The low rate response of hypothalamic self-stimulation behavior was markedly increased by triazolam at doses ranging from 2 to 40 mg/kg p.o., but was suppressed at doses over 80 mg/kg p.o. The high rate response was unaffected by triazolam even at doses of 40 ?? 180 mg/kg p.o. The low rate response was increased by diazepam at doses of 1 ?? 10 mg/kg p.o. and was suppressed at 80 mg/kg p.o. The high rate response was reduced by diazepam at 180 mg/kg p.o. In the conflict situation of the rat subjected to food reward and foot-shock punishment, the lever press response in the unpunished period was reduced by triazolam at doses of 1 ?? 5 mg/ kg p.o., whereas that in the punished period was markedly increased. Similar effects were observed with diazepam at doses of 15 ?? 20 mg/kg p.o. Triazolam appeared to be 10 ?? 15 times more potent than diazepam in this anticonflict effect. Thus, triazolam appears to be a potent antianxiety agent.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 74 (5), 615-628, 1978
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679248676096
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- NII Article ID
- 130000758945
- 30034987872
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaE1cXlsFOnsrk%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 1959147
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- PubMed
- 29828
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- Text Lang
- ja
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed