乳仔期三環系抗うつ薬投与によるラット体温調節系機能発達の変化とその性差

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  • Sex-related alterations in the functional development of the thermoregulatory system of rats exposed to tricyclic antidepressants during an infantile period.
  • ニュウシキ 3カンケイ コウウツクスリ トウヨ ニ ヨル ラット タイオン チ

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Five mg/kg of imipramine (IMI) or desipramine (DMI) was injected s.c. to Wistar-Imamichi male and female rats daily from 7 ?? 19 days of age. Control pups received saline. The body temperature of IMI-females showed a significant rise at 7, 8 and 12 weeks of age. Thermic responses to thyrotropin-releasing hormone (TRH, 10 mg/kg, i.p.) at 5 weeks of prepubertal age showed no marked changes. At 9 weeks of age, IMI-males showed a significant hyperthermia 15 ?? 30 min after TRH. Control and IMI-males were castrated at 9 weeks of age. At 11 weeks of age, castrated IMI-males showed a significant decrease in the TRH-induced hyperthermia compared to sham-operated or intact IMI-males. These castrated male rats were treated with a single dose of 20 mg/kg of testosterone enanthate (s.c.) at 11 weeks of age. There was no significant difference in the TRH-induced hyperthermia between the groups when tested at 13 weeks of age. Results suggest that the exposure of the infantile rats to imipramine induces sex-related functional alterations in the thermoregulatory system after puberty and that sex hormones may play a modulatory role for these changes.

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