シグナル伝達と細胞機能調節　細胞系におけるＣａ｀２＋´／カルモジュリン依存性プロテインキナーゼＩＩの細胞刺激に反応した調節

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タイトル別名
  • Regulation of Ca2+/calmodulin-dependent protein kinase II in the cell systems in response to cellular stimuli.
  • サイボウケイ ニ オケル Ca2 + カルモジュリン イゾンセイ プロテイン
  • シグナル伝達と細胞機能調節

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説明

Calcium ion (Ca2+) is considered to be involved in the regulation of numerous cellular processes. CaM kinase II is present at the highest concentration in the brain and is considered to be involved in the regulation and coordination of numerous cellular processes. CaM kinase II is activated by Ca2+ /calmodulin and simultaneously undergoes autophosphorylation. It has not been determined whether the enzyme is activated in the cell systems in response to the increase in cytoplasmic Ca2+ concentration. We have studied CaM kinase II in several kinds of cells including the primary cultures of cerebellar granule cells and the cell lines of rat embryo fibroblast 3Y1 cells, neuroblastoma cells, PC12 cells and C6 glioma cells. The immunohistochemical analysis demonstrated the presence of CaM kinase II in all of the cells examined. Furthermore, the kinase in cerebellar granule cells was activated by the stimulation of the glutamic acid receptor. Autophosphorylation of CaM kinase II in 3Y1 cells was stimulated by the addition of growth factors. These results suggest that CaM kinase II undergoes activation and autophosphorylation in response to various stimuli to the cells and is regulated in the dynamic state.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 98 (3), 177-185, 1991

    公益社団法人 日本薬理学会

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