Slow reacting substance of anaphylaxis(SRS‐A)の遊離および平滑筋収縮に及ぼすTranilastの影響
書誌事項
- タイトル別名
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- Effect of tranilast on the release of slow reacting substance of anaphylaxis (SRS-A) and on its contraction of smooth muscle
- Slow reacting substance of anaphylaxis
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説明
Slow reacting substance of anaphylaxis (SRS-A) and slow reacting substance (SRS) were released from actively sensitized guinea-pig lung with bovine serum albumin and from rat peritoneal exudate cells with ionophore A23187, respectively. FPL55712 markedly inhibited the contraction induced by SRS-A and SRS in guinea-pig ileum which was treated with atropine (10-7g/ml), mepyramine (10-6g/ml), and cyproheptadine (10-7g/ml). Tranilast and isoproterenol markedly suppressed the release of SRS-A in a dose-dependent manner; the concentrations of these drugs that gave 50% inhibition (IC50) were 1.1×10-4M and 8.3×10-9M, respectively. Although the inhibitory effect of tranilast (10-3M) was not affected in the presence of propranolol (3×10-6M), the inhibitory effect of isoproterenol was greatly diminished by propranolol. Also, tranilast markedly suppressed the release of SRS in a dose-dependent manner, its IC50 being 6.4×10-5M. However isoproterenol slightly inhibited the release of SRS. Disodium cromoglycate did not suppressed the release of SRS-A at all, and it suppressed SRS release a little. Tranilast inhibited the contraction induced by leukotriene C4 (0.5 ng/ml) and D4 (1 ng/ml) in guinea-pig trachea in a dose-dependent manner; the IC50 values were 2.2×10-4M and 2.0×10-4M, respectively, for these inhibitions. These results suggest that the inhibition of SRS-A release and SRS-A-induced contraction of smooth muscle by tranilast participates in the anti-asthmatic effect of tranilast, and its inhibitory mechanism is different from that of isoproterenol.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 82 (1), 47-55, 1983
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679248857088
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- NII論文ID
- 130000760578
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaL3sXkvF2jurY%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 2636455
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- PubMed
- 6194082
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可