Effects of Theo-Esberiven on the coronary circulation and myocardial metabolisms in dogs.
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- SAKAI Ken
- フナイ薬品工業株式会社・総合研究所
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- MIZUSAWA Hideo
- フナイ薬品工業株式会社・総合研究所
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- SAKANASHI Matao
- Department of Pharmacology, Kumamoto University Medical School
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- SAKAMOTO Kimihiro
- Department of Pharmacology, Kumamoto University Medical School
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- TAKEO Satoshi
- Department of Pharmacology, Kumamoto University Medical School
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- TAKENAKA Fumio
- Department of Pharmacology, Kumamoto University Medical School
Bibliographic Information
- Other Title
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- テオ‐エスベリベンのイヌ冠状循環動態および心筋代謝に及ぼす影響
- Theo Esberiven ノ イヌ カンジョウ ジュンカン ドウタイ オヨ
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Abstract
In isolated dog heart, Theo-Esberiven 0.1 mg, which contains 12 mg proxyphylline, 2.5 mg rutin and 5 mg Melilotus extract, and proxyphylline (12 mg) increased coronary blood flow (CBF) and was associated with increased heart rate (HR) and myocardial contractile force (MCF). The effect of Theo-Esberiven on CBF was about 1.7 times higher than that of proxyphylline. Theo-Esberiven did not significantly affect myocardial oxygen consumption (QO2) and redox potential (ΔEh), while proxyphylline aggravated myocardial metabolisms, as determined from these parameters. Esberiven 0.1 ml, which contains 2.5 mg rutin and 5 mg Melilotus extract, slightly but significantly increased CBF and decreased QO2 and ΔEh without changing HR and MCF. In situ, intra-coronary injection of either Theo-Esberiven or proxyphylline resulted in a dose-dependent increase in left circumflex coronary flow (LCCF). The effect of Esberiven on LCCF was much less and was slight at the higher doses. Intravenous injection of Theo-Esberiven (0.1 ml/kg) increased LCCF. Besides this change, marked fall in blood pressure and tachycardia were induced by both Theo-Esberiven and proxyphylline without the change in dP/dtmax. Esberiven by the same route led to the decrease in blood pressure associated with HR and dP/dtmax. These results indicate that Theo-Esberiven may be appropriately prescribed for ischemic heart diseases.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 74 (1), 37-47, 1978
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679248996608
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- NII Article ID
- 130000758885
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaE1cXktVSiurc%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 1925887
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- PubMed
- 640535
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed