Anti-inflammatory, analgesic and anti-pyretic activities of a new anti-inflammatory compound, 2-(4-(3-methyl-2-butenyl)phenyl) propionic acid (TA), in experimental animals.

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  • 新規非ステロイド系抗炎症物質２‐〔４‐（３‐Ｍｅｔｈｙｌ‐２‐ｂｕｔｅｎｙｌ）ｐｈｅｎｙｌ〕ｐｒｏｐｉｏｎｉｃ　ａｃｉｄ（ＴＡ）の抗炎症・鎮痛・解熱作用
  • シンキ ヒ ステロイドケイ コウ エンショウ ブッシツ 2 4 3 Methy

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Abstract

Anti-inflammatory, analgesic and anti-pyretic activities of orally administered TA were investigated in experimental animals. Against acetic acid-induced vascular permeability in mice, carrageenin-induced hind paw edema in rats and ultra-violet ray-induced erythema in guinea pigs, TA produced a dose related inhibition at doses of 40 ?? 160 mg/kg, 10 ?? 40 mg/kg and 10 ?? 40 mg/kg, respectively. TA produced no inhibition against histamine-induced vascular permeability even at a dose of 200 mg/kg in rats. Cotton pellet-induced granuloma and adjuvant-induced arthritis in rats were significantly inhibited by repeated administration of TA at a dose of 50 mg/kg/day for 6 days and 25 mg/kg/day for 6 days, respectively. TA showed a dose related analgesic effect at a dose of 50 ?? 200 mg/kg in acetic acid writhing, Randall-Selitto and adjuvant arthritic pain methods. A high dose of TA was needed to produce an analgesic effect in the pressure method using mice. TA produced an anti-pyretic effect against the pyrexia induced by yeast in rats. On the other hand, TA showed no effect against normal body temperature in rats. These results suggest that anti-inflammatory, analgesic and anti-pyretic activities of TA are generally a little weaker than those of ibuprofen, and the mode of action of TA is similar to that of a typical acidic non-steroidal anti-inflammatory drug such as ibuprofen, indomethacin or phenylbutazone. The ulcerogenic activity of TA was about 2 and 4 times weaker than that of ibuprofen in rats and mice, respectively. TA showed a protective effect against gastric necrosis induced by HCl. In conclusion, TA is a potent anti-inflammatory compound, and the slight ulcerating effect of TA on the stomach may be attributed to its protective effect on the gastric mucous membrane.

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