Effect of moxisylyte on the lower urinary tracts. (2). Effect on the urethra in anesthetized dogs.
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- WATANABE Kiyoshi
- Pharmaceuticals Research Laboratories, Fujirebio Inc.
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- HAYASHI Yutaka
- Pharmaceuticals Research Laboratories, Fujirebio Inc.
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- IKEDA Kenro
- Pharmaceuticals Research Laboratories, Fujirebio Inc.
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- OHNISHI Haruo
- Pharmaceuticals Research Laboratories, Fujirebio Inc.
Bibliographic Information
- Other Title
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- Moxisylyteの下部尿路系に対する作用―2 生体位尿道に対する作用
- Moxisylyte ノ カブ ニョウロケイ ニ タイスル サヨウ 2 セイタ
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Abstract
Effect of moxisylyte on the lower urinary tracts was studied with the urethral pressure profile (UPP) and balloon method in anesthetized female dogs. In the UPP, moxisylyte produced relaxation in both the proximal and distal urethras. The relaxation effects of prazosin and bunazosin on the distal urethra was weaker than on the proximal urethra. In the balloon method, moxisylyte, prazosin, bunazosin and phentolamine caused a decrease in urethral pressure dose-dependently. The ID25 values of moxisylyte, prazosin, bunazosin and phentolamine were 23.4, 0.43, 0.76 and 33.1 μg/kg, respectively. In the balloon method, moxisylyte noncompetitively antagonized phenylephrine induced contraction of the urethra at high doses, whereas prazosin, bunazosin, phentolamine and yohimbine competitively antagonized phenylephrine induced contraction of the urethra. These results suggest that moxisylyte relaxes both the proximal and distal urethras due to α1-adrenoceptor antagonistic and direct urethral smooth muscle relaxant actions. Therefore, moxisylyte is useful for the therapeutic treatment of micturitional disorder.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 97 (3), 153-165, 1991
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679249265152
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- NII Article ID
- 130000758959
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- NII Book ID
- AN00198335
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 3736924
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- PubMed
- 1674929
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed