Effect of tranilast, an anti-allergic drug, on the human keloid tissues.
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- SUZAWA Haruo
- Medical Information, Kissei Pharmaceutical Co., Ltd.
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- KIKUCHI Shinji
- Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd.
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- ICHIKAWA Kiyoshi
- Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd.
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- ARAI Nobuhiko
- Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd.
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- TAZAWA Shigeki
- Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd.
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- TSUCHIYA Okinori
- Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd.
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- MOMOSE Yasunori
- Second Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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- SHIBATA Nobuo
- Second Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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- SUGIMOTO Chitou
- Department of Plastic and Reconstructive Surgery, Keio University
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- HAMANO Shuichiro
- Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd.
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- KOMATSU Hidetada
- Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd.
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- MIYATA Hiroshi
- Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd.
Bibliographic Information
- Other Title
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- アレルギー性疾患治療薬Tranilastのケロイド組織に対する作用
- アレルギーセイ シッカン チリョウヤク Tranilast ノ ケロイド ソシ
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Abstract
We studied the inhibitory effects of tranilast, an anti-allergic drug, on the human keloid tissues implanted into the dorsal skin of athymic nude mice and on the growth of keloid fibroblast in vitro. In the keloid tissue-implanted model, tranilast (50 ?? 200 mg/kg, p.o.) decreased the weight of the keloid tissue as triamcinolone (25 mg/kg, p.o.) did. Tranilast (200 mg/kg, p.o.) reduced the hydroxyproline content of implanted tissues. Tranilast (3 ?? 300 μM) also inhibited the collagen synthesis by keloid fibroblast in vitro. Only a high concentration of tranilast (300 μM) suppressed the glycosaminoglycan synthesis and cell proliferation of keloid fibroblasts. Moreover, tranilast scarcely affected the fibronectin production. Triamcinolone (10 μM) also inhibited glycosaminoglycan synthesis and cell proliferation. These results suggest that the inhibitory effect of tranilast on the keloid tissues is related to its inhibition of the collagen synthesis of fibroblasts. Tranilast would be useful as a therapeutic drug for the treatment of keloids.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 99 (4), 231-239, 1992
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679249459584
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- NII Article ID
- 130000758772
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaK38Xkt1Sis7c%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 3776975
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- PubMed
- 1376711
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed