ドーパミン系除神経ラットの線条体へ移植した胎仔神経細胞による運動機能の改善

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  • Functional improvement produced by transplantation of fetal neuronal cell suspensions in the rat striatum with 6-hydroxydopamine lesions.
  • ドーパミンケイ ジョシンケイ ラット ノ センジョウタイ ヘ イショクシタ タ

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Behavior improvement from apomorphine-induced rotation, morphological features of nerve cells and in vivo release of dopamine (DA) were examined after the implantation of neuronal cell suspensions into the striatum of female rats with 6-hydroxydopamine lesions. Apomorphine-induced rotation was significantly suppressed in 11 out of 26 rats from two through ten weeks after the implantation. In 3 out of 26 rats, the rotation was significantly suppressed for four weeks after the implantation, although the suppression was reversed by the fifth week. In the remaining 12 rats, the rotation was not inhibited after the implantation. Behavior improvement was concurrent with extension of neurites from anti-DA immunopositive cells to the host caudate. Anti-DA cells were very scant in the absence of behavior improvement. In vivo release of DA and the metabolites, 3, 4-dihydroxyphenylacetic acid and homovanillic acid, was detected in the perfusates of the striatum of the animals that were functionally improved by the transplant. Methamphetamine caused an increase in DA release and a decrease in the release of the metabolites in those animals. These results suggest that grafted neuronal cells which are sensitive to methamphetamine probably innervate neuronal elements in the host caudate, and the release of DA from these grafted cells functionally affects behavior improvement.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 90 (2), 125-132, 1987

    公益社団法人 日本薬理学会

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