書誌事項
- タイトル別名
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- Dopamineinduced up-regulation of .ALPHA.2-adrenoceptors in crude synaptic membranes of rat brain.
- Dopamine ニ ヨル ラット ノウ シナプス マク アルファ2アドレノセ
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抄録
After cerebral cortical membranes were incubated with 0.1-100 μM of dopamine (DA) in 50 mM Tris-HCl buffer (pH 7.7) at 37°C for 30 min, [3H] clonidine binding to α2-receptors was increased in a concentration-dependent manner without changing [3H] WB4101 and [3H] DHA binding to α1- and β-receptors, respectively. Scatchard analysis of [3H] clonidine binding to cortical membranes showed that DA increased the Bmax in both high- and low-affinity components. The increasing effect of DA on [3H] clonidine binding was dependent on incubation time and temperature, and it was antagonized by pimozide and cis-flupenthixol. The addition of GTP produced a reduction in DA-induced elevation in [3H] clonidine binding, while that of cyclic AMP did not affect the effect of DA. DA and Mn2+, though both of them increased [3H] clonidine binding, appeared to act at a different site in the membrane. Furthermore, the DA-induced increase in [3H] clonidine binding was found uniformly in membranes prepared from 7 other regions of the rat brain. These results suggested that DA regulates specifically α2-receptor density by stimulating D1-receptors and/or via other mechanism(s).
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 85 (3), 173-183, 1985
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679249538048
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- NII論文ID
- 130000761763
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaL2MXhs1SqtL8%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 3025113
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- PubMed
- 2989130
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
